Tildipirosin
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Tildipirosin
Tildipirosine ni ubwoko bushya bwa kimwe cya kabiri cya sintetike igizwe na 16 igizwe nimpeta ya macrolide antibiyotike y’inyamaswa, ikomoka kuri tylosine.
Igikorwa cya farumasi
Ingaruka ya antibacterial ya Tildipirosine isa n'iya tylosine, kandi igira ingaruka zikomeye zo guhagarika bagiteri nziza ya Gram na bagiteri zimwe na zimwe za Gram-mbi.Uburyo bwa antibacterial ya Tildipirosin ni bumwe na macrolide.Irashobora guhuza na 50S subunit ya ribosome ya bagiteri yoroheje kugirango ibuze guhuza iminyururu ya peptide ya riboprotein, bityo bikagira ingaruka kuri synthesis ya proteine za bagiteri.Imikoranire yibice bibiri bya piperidine yihariye ya Tildipirosine itandukanya uburyo bwimikorere yibi biyobyabwenge na tylosine na tilmicosine, aho piperidine 20 yerekeza mumyanya kugirango ibangamire imikurire ya peptide ikivuka.
Kuberako tediroxine ifite amatsinda 3 yibanze ya amino, irashobora gukora uburyo butandukanye bwishyuzwa mubihe bitandukanye bya pH.Umubare w'amafaranga ni ikintu cy'ingenzi cyangiza ubukana bwa lipide ya bagiteri no kwinjira mu gice cyo hanze cya Gram-negative bacteria, bityo ibikorwa bya bacteriostatike ya Tildipirosine muri vitro bigira ingaruka cyane kuri pH.Mugihe cya acide, itsinda rya amino riba protonone, bigatuma igabanuka ryibikorwa bya antibacterial ya tediroxine, mugihe mubihe bya alkaline, ifite ibikorwa bya antibacterial.
Macrolide ibuza gusohora cytokine ya proinflammatory, ibikorwa bya fosifolipase, no kurekura leukotriene, kandi bigira ingaruka zo kurwanya inflammatory muri macrophage na neutrophile.Tediroxine igabanya abunzi baterana mugihe cyo gukemura ibibazo.
Indwara ya antibacterial
Tildipirosine igira ingaruka nziza kuri bagiteri zitera indwara zubuhumekero mu ngurube no mu nka (nka Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, Mannheim spp. Nibindi) ibikorwa bya antibacterial ya tilmicosine byikubye inshuro 2-32. , kandi ibikorwa bya antibacterial kurwanya amara Escherichia coli byari byiza kuruta tylosine na tilmicosine.Irumva kandi ubwoko bumwe na bumwe bwa mycoplasma, spirochette, brucella, nibindi. Ubushakashatsi bwerekanye ko tediroxine igira ingaruka zikomeye za bacteriostatike kuri Haemophilus parasuis na Bordetella bronchiseptica kuruta florfenicol, ariko ingaruka za bacteriostatike nkeya kuri Actinobacillus pleuropneumoniae na Pasteurella multocida.Tildipirosine ni bagiteri yica bagiteri zimwe na zimwe (nka Haemophilus parasuis na Actinobacillus pleuropneumoniae), mu gihe usanga ari bacteriostatike kuri bagiteri zimwe na zimwe (nka Pasteurella multocida).Kuri bagiteri zo munda, hamwe no kugabanuka kwagaciro ka pH (kuva 7.3 kugeza 6.7), MIC ya Tildipirosin yiyongereye, kurugero, MIC ya Tildipirosin irwanya Salmonella Enteritidis na Escherichia coli irashobora kwiyongera kuva 2 ~ 8ug / m ikagera kuri 64 ~ 256ug / mL .Kubwibyo, ingaruka zimpinduka za pH muri vivo zigomba gusuzumwa mugihe ukora test ya vivo antibacterial test ya Tildipirosin.Byongeye kandi, MIC ya Tildipirosine irwanya ubwoko busanzwe bwa Pasteurella multocida yari 0.5ug / mL muri serumu, ikaba yari munsi ya 0.25 ugereranije na vitro, ishobora kuba ifitanye isano n'ingaruka za serumu.
Enterococcus-Streptococcus mu nka z’amata irwanya cyane tediroxine.Tildipirosin ntiyumva Pasteurella multocida na Mannheimia haemolyticus itwara genes za mutant.Mu buryo nk'ubwo, ubwoko bwahinduwe na genetike ya M. bovis irwanya antibiyotike ya macrolide harimo na Tildipirosine.Ubwoko bumwe na bumwe bwa parasuis ya Haemophilus nabwo bwagaragaye ko busanzwe burwanya tediroxine.Mycoplasma bovis irashobora kubona vuba kurwanya Tildipirosine, ariko kubera gukura kwa Mycoplasma gahoro, mugupima imiti ya vitro irashobora gutinda kuvurwa.Ubushakashatsi bwerekanye ko domaine II (nucleotide 748) na domaine V (Guhinduka muri nucleotide 2059 na 2060) bifitanye isano no kurwanya macrolide.Kubwibyo, kwandura M. bovis kumiti ya macrolide birashobora kuboneka byihuse mugupima molekile yiyi mutation.
Ibirimo
≥ 98%
Ibisobanuro
Ibipimo bya sosiyete
Hebei Veyong pharmaceutical Co., Ltd yashinzwe mu 2002, iherereye mu mujyi wa Shijiazhuang, Intara ya Hebei, mu Bushinwa, iruhande rw’umurwa mukuru wa Beijing.Ni ikigo kinini cyemewe na GMP cyemewe n’ibiyobyabwenge, hamwe na R&D, gukora no kugurisha amatungo ya APIs, imyiteguro, ibiryo byateganijwe hamwe ninyongeramusaruro.Nka Centre Tekinike yintara, Veyong yashyizeho uburyo bushya bwa R&D kumiti yubuvuzi bwamatungo, kandi nicyo kigo kizwi cyane mu guhanga udushya mu ikoranabuhanga rishingiye ku buvuzi bw’amatungo, hari abahanga mu bya tekinike 65.Veyong ifite ibishingwe bibiri: Shijiazhuang na Ordos, muri byo ikigo cya Shijiazhuang gifite ubuso bwa m2 78,706 m2, hamwe n’ibicuruzwa 13 bya API birimo Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, n'imirongo 11 yo gutegura harimo gutera inshinge, igisubizo cyo mu kanwa, ifu , premix, bolus, imiti yica udukoko hamwe na disinfectant, ects.Veyong itanga APIs, zirenga 100 bwite- label itegura, na serivisi ya OEM & ODM.
Veyong yita cyane ku micungire ya sisitemu ya EHS (Ibidukikije, Ubuzima & Umutekano), kandi yabonye impamyabumenyi ya ISO14001 na OHSAS18001.Veyong yashyizwe ku rutonde rw’inganda zigenda ziyongera mu Ntara ya Hebei kandi irashobora gutanga ibicuruzwa bikomeza.
Veyong yashyizeho uburyo bwuzuye bwo gucunga neza, yabonye icyemezo cya ISO9001, icyemezo cya GMP mu Bushinwa, icyemezo cya Ositarariya APVMA GMP, icyemezo cya Etiyopiya GMP, icyemezo cya Ivermectin CEP, kandi yatsinze igenzura rya FDA muri Amerika.Veyong ifite itsinda ryumwuga ryo kwiyandikisha, kugurisha na serivisi ya tekiniki, isosiyete yacu imaze kwiringira no gushyigikirwa nabakiriya benshi kubwiza bwibicuruzwa byiza, ubuziranenge bwiza mbere yo kugurisha na nyuma yo kugurisha, gucunga neza na siyansi.Veyong yakoze ubufatanye burambye n’inganda nyinshi zizwi cyane mu bya farumasi y’imiti n’ibicuruzwa byoherezwa mu Burayi, Amerika y'Epfo, Uburasirazuba bwo hagati, Afurika, Aziya, n'ibindi bihugu birenga 60.
