Ivermectin
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Ivermectin
Ivermectinni ifu yera ya kristaline, impumuro nziza.Irashobora gushonga kubuntu muri methanol, Ethanol, acetone, Ethyl acetate, muburyo budashobora gushonga mumazi, hamwe na hygroscopique.Ivermectin ni semisintetike ya macrolide ya antibiyotike igizwe nibice byinshi, irimo cyane cyane ivermectin B1 (Bla + B1b) ibirimo munsi ya 95%, muri byo Bla ikaba itari munsi ya 85%.
Ihame ry'ubuvuzi
Ivermectin igira ingaruka zo guhitamo, muguhuza cyane cyane imiyoboro ya chloride hamwe na glutamate nka valve mumyanya myakura ningirangingo yimitsi yinyamaswa zidafite izunguruka, ibyo bigatuma habaho kwiyongera kwimikorere yibice bigize selile ya ion ya chloride, bitera hyperpolarisation ya selile nervice. cyangwa ingirangingo z'imitsi, kandi itera ubumuga cyangwa urupfu rwa parasite.Ihuza kandi n'imiyoboro ya chloride yandi marenga ya ligand, nka acide neurotransmitter g-aminobutyric aside (GABA).Guhitamo ibicuruzwa ni ukubera ko inyamaswa z’inyamabere zimwe na zimwe zidafite imiyoboro ya glutamate-chloride muri vivo, kandi avermectin ifitanye isano rito gusa n’imiyoboro y’inyamabere ya ligand-chloride.Iki gicuruzwa ntigishobora gucengera inzitizi yamaraso yubwonko bwabantu.Onchocerciasis na strongyloidiasis na hookworm, ascaris, Trichuris trichiura, na Enterobius vermicularis.
Gukoresha
Ivermectin ni imiti ikoreshwa mu kuvura ubwoko bwinshi bwa parasite.Ivermectin ikoreshwa mu kuvura indwara zinyamaswa ziterwa ninzoka zangiza na ectoparasite.
Ivermectin isanzwe ikoreshwa muguhashya inyo za parasitike mu nzira ya gastrointestinal yinyamanswa.Izi parasite mubisanzwe zinjira mu nyamaswa iyo zirisha, zinyura mu mara, hanyuma zigashyira kandi zikuze mu mara, nyuma zikabyara amagi asiga inyamaswa akoresheje ibitonyanga kandi ashobora gutera urwuri rushya.Ivermectin ifite akamaro mukwica bamwe, ariko sibyose, murizo parasite.Mu mbwa ikoreshwa bisanzwe nka prophylaxis irwanya umutima.
Mubuvuzi bwamatungo, bukoreshwa mukurinda no kuvura indwara yumutima na acariasis, mubindi bimenyetso.Irashobora gufatwa numunwa cyangwa igashyirwa kuruhu kugirango yanduze hanze.Ivermectin ikoreshwa cyane kuri nematode ya gastrointestinal, inzoka zo mu bihaha, na arthropods ya parasitike mu nka, intama, amafarasi, n'ingurube, nematode yo mu nda mu mbwa, miti y'amatwi, Sarcoptes scabiei, umutima filariae, na microfilariae, na gastrointestinal nematode na ectoparasite.
Imyiteguro
Ivermectin bolus;
Ivermectin isuka kumuti 0.5%, 1%;
Ivermectin gel 0.4%
Hebei Veyong pharmaceutical Co., Ltd yashinzwe mu 2002, iherereye mu mujyi wa Shijiazhuang, Intara ya Hebei, mu Bushinwa, iruhande rw’umurwa mukuru wa Beijing.Ni ikigo kinini cyemewe na GMP cyemewe n’ibiyobyabwenge, hamwe na R&D, gukora no kugurisha amatungo ya APIs, imyiteguro, ibiryo byateganijwe hamwe ninyongeramusaruro.Nka Centre Tekinike yintara, Veyong yashyizeho uburyo bushya bwa R&D kumiti yubuvuzi bwamatungo, kandi nicyo kigo kizwi cyane mu guhanga udushya mu ikoranabuhanga rishingiye ku buvuzi bw’amatungo, hari abahanga mu bya tekinike 65.Veyong ifite ibishingwe bibiri: Shijiazhuang na Ordos, muri byo ikigo cya Shijiazhuang gifite ubuso bwa m2 78,706 m2, hamwe n’ibicuruzwa 13 bya API birimo Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, n'imirongo 11 yo gutegura harimo gutera inshinge, igisubizo cyo mu kanwa, ifu , premix, bolus, imiti yica udukoko hamwe na disinfectant, ects.Veyong itanga APIs, zirenga 100 bwite- label itegura, na serivisi ya OEM & ODM.
Veyong yita cyane ku micungire ya sisitemu ya EHS (Ibidukikije, Ubuzima & Umutekano), kandi yabonye impamyabumenyi ya ISO14001 na OHSAS18001.Veyong yashyizwe ku rutonde rw’inganda zigenda ziyongera mu Ntara ya Hebei kandi irashobora gutanga ibicuruzwa bikomeza.
Veyong yashyizeho uburyo bwuzuye bwo gucunga neza, yabonye icyemezo cya ISO9001, icyemezo cya GMP mu Bushinwa, icyemezo cya Ositarariya APVMA GMP, icyemezo cya Etiyopiya GMP, icyemezo cya Ivermectin CEP, kandi yatsinze igenzura rya FDA muri Amerika.Veyong ifite itsinda ryumwuga ryo kwiyandikisha, kugurisha na serivisi ya tekiniki, isosiyete yacu imaze kwiringira no gushyigikirwa nabakiriya benshi kubwiza bwibicuruzwa byiza, ubuziranenge bwiza mbere yo kugurisha na nyuma yo kugurisha, gucunga neza na siyansi.Veyong yakoze ubufatanye burambye n’inganda nyinshi zizwi cyane mu bya farumasi y’imiti n’ibicuruzwa byoherezwa mu Burayi, Amerika y'Epfo, Uburasirazuba bwo hagati, Afurika, Aziya, n'ibindi bihugu birenga 60.
